Resolution of Inflammation, Statins, and Plaque Regression
نویسندگان
چکیده
منابع مشابه
Fenofibrate, statins, and inflammation.
To the Editor: I recently read the review by Berg et al, about tissue, inflammation, and cardiovascular disease.1 Although the review discusses our research on ligands for peroxisome proliferator activated receptor (PPAR), we used fenofibrate, a PPARactivator, not glitazones, PPARagonists, as the review suggests.2 We also found that statins non-significantly lower serum adiponectin levels, not ...
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Clinical trials of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statin therapy demonstrate an improvement in cardiovascular end points and coronary stenosis. However, an improvement in cardiovascular end points and coronary stenosis is incompletely explained by the baseline or treated LDL cholesterol level. The beneficial effects of statins on clinical events may invo...
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OBJECTIVE We previously demonstrated that subjects with functional ATP-binding cassette (ABC) A1 mutations have increased atherosclerosis, which has been attributed to the role of ABCA1 in reverse cholesterol transport. More recently, a proinflammatory effect of Abca1 deficiency was shown in mice, potentially contributing to atherogenesis. In this study, we investigated whether ABCA1 deficiency...
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Sepsis and septic shock are complex inflammatory syndromes. Multiple cellular activation processes are involved, and many humoral cascades are triggered. Statins have anti-inflammatory properties. Our preliminary observations indicate that patients receiving therapy with statins may have a lower incidence of severe sepsis. We hypothesize that statins have a strong protective effect against seps...
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Atherosclerosis is a maladaptive, nonresolving chronic inflammatory disease that occurs at sites of blood flow disturbance. The disease usually remains silent until a breakdown of integrity at the arterial surface triggers the formation of a thrombus. By occluding the lumen, the thrombus or emboli detaching from it elicits ischaemic symptoms that may be life-threatening. Two types of surface da...
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ژورنال
عنوان ژورنال: JACC: Cardiovascular Imaging
سال: 2012
ISSN: 1936-878X
DOI: 10.1016/j.jcmg.2012.01.002